Purpose Pertinent literature regarding the potential use of testosterone therapy in men with prostate cancer is reviewed and synthesized.
Materials and Methods A literature search was performed of English language publications on testosterone administration in men with a known history of prostate cancer and investigation of the effects of androgen concentrations on prostate parameters, especially prostate specific antigen.
Andrologia. 2012 Dec;44(6):405-10. doi: 10.1111/j.1439-0272.2012.01296.x. Epub 2012 Apr 23.
S-testosterone decrease after a mixed meal in healthy men independent of SHBG and gonadotrophin levels.
The exercise plus testosterone group experienced improvements from baseline in peak oxygen uptake (P<.01), Beck Depression Inventory (P<.05), leg strength (P<.05) and several Medical Outcomes Study Short-Form quality of life domains (P<.05). These improvements were generally not observed in the exercise plus placebo group, according to the abstract. Similar improvements in shuttle walk test (18% vs. 19%), body mass (–1.3 kg vs. –1 kg) and hand grip strength (2.1 kg vs. 2.5 kg) from baseline to 12 weeks were recorded in both groups.
More on fatty liver and its consequences:
Nonalcoholic fatty liver disease is now the most common cause of chronic liver disease in the U.S. Some people with excess fat in the liver simply have what's called a fatty liver. Although this is not normal, it is not serious if it doesn't lead to inflammation or damage.